Aortic pulse wave velocity ≥10 m/s was a strong independent predictor of all-cause mortality in patients with chronic kidney disease stages 2-4 (HR 5.1; 95% CI 1.1-22.9).
Observational (n=135)
Does increased aortic pulse wave velocity predict mortality and renal disease progression in patients with CKD stages 2-4?
In patients with mild-to-moderate CKD (stages 2-4), increased aortic stiffness measured by aPWV ≥10 m/s is a strong independent predictor of all-cause mortality.
Effect estimate: HR 5.1 (95% CI 1.1-22.9)
p-value: p=<0.05
BACKGROUND: Chronic kidney disease (CKD) is characterized by aortic stiffness and increased cardiovascular mortality. In end-stage renal disease, aortic stiffness predicts mortality, whereas this role remains uncertain in mild-to-moderate CKD. We aimed to investigate whether aortic pulse wave velocity (aPWV) predicts mortality and renal disease progression in CKD patients. METHODS: We enrolled 135 CKD patients stages 2-4 estimated glomerular filtration rate (eGFR): 41.1 (28.5-61.6) ml/min per 1.73 m in the study and assessed aPWV. The combined renal end-point was defined as at least 50% decline in renal function and/or start of renal replacement therapy. RESULTS: During the observational period of 42 (30-50) months six patients were lost of follow-up, 13 patients died and 16 patients reached the combined renal end-point. Stratification according to the mean of aPWV (10 m/s), Kaplan-Meier analysis revealed increased mortality with aPWV ≥10 m/s (log-rank P < 0.05). Stepwise logistic regression analysis confirmed aPWV as an independent predictor for mortality in CKD stage 2-4. The hazard ratio of mortality in the cohort with an aPWV at least 10 m/s was 5.1 (1.1-22.9). By contrast, Kaplan-Meier analysis revealed no effect of aPWV on the combined renal end-point (log-rank P = 0.90). DISCUSSION: These results provide the first direct evidence that in patients with CKD stage 2-4, increased aortic stiffness determined by aPWV is a strong independent predictor of all-cause mortality.
Baumann et al. (Thu,) conducted a observational in Chronic kidney disease stages 2-4 (n=135). Aortic pulse wave velocity (aPWV) ≥10 m/s vs. aPWV <10 m/s was evaluated on Mortality (HR 5.1, 95% CI 1.1-22.9, p=<0.05). Aortic pulse wave velocity ≥10 m/s was a strong independent predictor of all-cause mortality in patients with chronic kidney disease stages 2-4 (HR 5.1; 95% CI 1.1-22.9).