October 1, 1999

Characterization of Conduction in the Ventricles of Normal and Heterozygous Cx43 Knockout Mice Using Optical Mapping

Structured PICO

Population

Normal (wild-type) and heterozygous Cx43 knockout (Cx43+/-) mice

Comparator

Wild-type mice

Outcome

Local conduction velocities (CVs) throughout the ventricles and ECG parameter valuessurrogate

Heterozygous knockout of Cx43 does not alter ventricular conduction velocities or ECG parameters in mice.

Abstract

A sensitive method that accurately measures local CVs throughout the ventricles revealed no changes in Cx43+/- mice, which is consistent with the demonstration that ECG parameter values in the heterozygous mice are the same as those in wild-type mice.

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Discussion

Authors

Gregory E. Morley

New York University

Dhananjay Vaidya

Preventive Cardiology

Faramarz H. Samie

Columbia University Irving Medical Center

Journals

Journal of Cardiovascular Electrophysiology

Actions

Institutions

University of Pennsylvania

Syracuse University

SUNY Upstate Medical University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Characterization of Conduction in the Ventricles of Normal and Heterozygous Cx43 Knockout Mice Using Optical Mapping

Structured PICO

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study