Type I diabetic patients without major complications had a lower peak filling rate at rest compared to normal subjects (4.1 vs 4.8 end-diastolic volumes/s; P<0.05).
Cross-Sectional (n=19)
Does uncomplicated type I diabetes mellitus impair cardiac diastolic function compared to normal subjects?
Uncomplicated type I diabetes mellitus is associated with impaired cardiac diastolic filling at rest and during exercise, which may represent the earliest functional effect of diabetic cardiomyopathy.
Absolute Event Rate: 4.1% vs 4.8%
p-value: p=<0.05
The presence of diabetic cardiomyopathy and its relationship to concurrent hormonal and metabolic status have not been defined in patients with uncomplicated type I diabetes mellitus. Accordingly, radionuclide left ventricular angiograms and simultaneous metabolic profiles were obtained in 8 type I diabetic patients who had no major diabetic complications and in 11 normal subjects. Occult coronary artery disease was excluded by electrocardiogram exercise testing. Hemodynamics and systolic function did not differ between the groups. However, the peak filling rate (PFR; end-diastolic volumes per s) was less in the diabetic patients at rest mean, 4.1 +/- 0.2 (+/- SE) vs. 4.8 +/- 0.2; P less than 0.05 and during aerobic (6.8 +/- 0.2 vs. 8.30 +/- 0.3; P less than 0.01) and anaerobic exercise (8.8 +/- 0.3 vs. 9.8 +/- 0.4; P less than 0.05). The time to PFR was prolonged in the diabetic patients at rest (174 +/- 10 vs. 133 +/- 7 ms; P less than 0.01) and during anaerobic exercise (126 +/- 5 vs. 103 +/- 6 ms; P less than 0.01). Plasma glucose and insulin levels were elevated in the diabetic patients at rest and during exercise. Otherwise, the metabolic and hormonal levels did not differ between the groups. In the diabetic patients, no single metabolic or hormonal parameter correlated with PFR or time to PFR. Impairment of diastolic filling also did not correlate with level of glycosylated hemoglobin or duration of diabetes. The alteration in diastolic filling present in type I diabetic patients who have no other diabetic complications may represent the earliest functional effect of diabetic cardiomyopathy.
Ruddy et al. (Fri,) conducted a cross-sectional in Type I diabetes mellitus (n=19). Type I diabetes mellitus vs. Normal subjects was evaluated on Peak filling rate (PFR) at rest (end-diastolic volumes per s) (p=<0.05). Type I diabetic patients without major complications had a lower peak filling rate at rest compared to normal subjects (4.1 vs 4.8 end-diastolic volumes/s; P<0.05).