Why the study?
Does uncomplicated type I diabetes mellitus impair cardiac diastolic function compared to normal subjects?
Population
8 type I diabetic patients with no major diabetic complications and 11 normal subjects
Comparison
Type I diabetes mellitus (observational exposure) vs Normal subjects
Design
Cross-sectional
Key result
Type I diabetic patients without major complications had a lower peak filling rate at rest compared to normal subjects (4.1 vs 4.8 end-diastolic volumes/s; P<0.05).
Authors
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May signal early diabetic cardiomyopathy in type 1 diabetes; hypothesis-generating and leaves open need for prospective validation.
Cross-Sectional (n=19)
Does uncomplicated type I diabetes mellitus impair cardiac diastolic function compared to normal subjects?
Absolute Event Rate: 4.1% vs 4.8%
p-value: p=<0.05
Uncomplicated type I diabetes mellitus is associated with impaired cardiac diastolic filling at rest and during exercise, which may represent the earliest functional effect of diabetic cardiomyopathy.
Ruddy et al. (1988) conducted a cross-sectional in Type I diabetes mellitus (n=19). Type I diabetes mellitus vs. Normal subjects was evaluated on Peak filling rate (PFR) at rest (end-diastolic volumes per s) (p=<0.05). Type I diabetic patients without major complications had a lower peak filling rate at rest compared to normal subjects (4.1 vs 4.8 end-diastolic volumes/s; P<0.05).