Key result
Type 1 diabetic patients had a longer corrected early apexcardiographic relaxation time after dynamic exercise compared to controls (38.7 vs 17.3 ms; p<0.001), indicating diastolic dysfunction.
Why the study?
Does dynamic exercise reveal left ventricular diastolic dysfunction in type 1 diabetic patients without overt heart disease compared to healthy controls?
Population
27 type 1 diabetic patients without overt heart disease and 50 age- and sex-matched control subjects
Comparison
Symptom-limited, graded dynamic exercise vs Age- and sex-matched healthy controls
Design
Case-control
Authors
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Exercise testing may unmask subclinical diastolic dysfunction in type 1 diabetes; hypothesis-generating and requires prospective validation.
Case-Control (n=77)
Does dynamic exercise reveal left ventricular diastolic dysfunction in type 1 diabetic patients without overt heart disease compared to healthy controls?
Absolute Event Rate: 38.7% vs 17.3%
p-value: p=<0.001
Dynamic exercise testing can unmask early left ventricular diastolic dysfunction in type 1 diabetic patients who have normal cardiac function at rest.
Jermendy et al. (2008) conducted a case-control in Type 1 Diabetes (n=77). Type 1 Diabetes vs. Age- and sex-matched controls was evaluated on Corrected early apexcardiographic relaxation time after dynamic exercise (p=<0.001). Type 1 diabetic patients had a longer corrected early apexcardiographic relaxation time after dynamic exercise compared to controls (38.7 vs 17.3 ms; p<0.001), indicating diastolic dysfunction.
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