Key result
Well-controlled type-I diabetes was associated with a significantly prolonged isovolumetric relaxation period compared to controls, independent of metabolic control or early microangiopathy.
Why the study?
Does well-controlled type-I diabetes alter left ventricular function compared to healthy controls?
Case-Control (n=100)
Does well-controlled type-I diabetes alter left ventricular function compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Caution against assuming normal LV function in well-controlled type 1 diabetes; leaves open predictive value for future events.
A high prevalence of left ventricular dysfunction in insulin-dependent (type-I) diabetics has been reported. However, the exact influence of metabolic control and/or the coexistence of early diabetic microangiopathy is unknown. Thus, we assessed left ventricular function by echophonocardiography in 50 type-I diabetics (mean age 26 +/- 7.9 years), who showed a fairly good metabolic long-term control (mean hemoglobin A1: 8.8%) after the introduction to intensified insulin therapy in comparison with 50 age- and sex-matched controls. Type-I diabetics did not differ from controls in their left ventricular internal diameters, mean wall thickness, ratio of pre-ejection period to left ventricular ejection time and systolic shortening fraction. Isovolumetric relaxation period reflecting an early diastolic event was slightly but significantly prolonged in diabetic subjects, independent of metabolic control status or existence of early microangiopathy. Isovolumetric relaxation period showed a statistically significant correlation to age in type-I diabetics, but not in controls. Possibly, the diabetic status--although well-controlled, but not normalized--may biochemically alter the myocardium and might influence its diastolic properties.
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Punzengruber et al. (2008) conducted a case-control in Insulin-dependent (type I) diabetes (n=100). Type-I diabetes (well-controlled) vs. Age- and sex-matched controls was evaluated on Left ventricular function parameters (including isovolumetric relaxation period). Well-controlled type-I diabetes was associated with a significantly prolonged isovolumetric relaxation period compared to controls, independent of metabolic control or early microangiopathy.
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