What question did this study set out to answer?

To evaluate left ventricular diastolic function at rest and during exercise in young men with long-term type 1 diabetes lacking overt heart disease.

April 1, 1988European Heart Journal

Left ventricular diastolic function in young long-term type 1 (insulin-dependent) diabetic men during exercise assessed by digitized echocardiography

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Why the study?

Does long-term type 1 diabetes impair left ventricular diastolic function at rest and during exercise in young men without overt heart disease?

Population

n=20 men, comprising 10 relatively young long-term type 1 diabetic men without overt heart disease, and 10…

Comparison

Semisupine bicycle exercise with digitized… vs Healthy controls undergoing the same exercise…

Design

Case-control

Authors

RDRagnar DaníelsenCardiac Imaging JNJan Erik NordrehaugInterventional Cardiology HVHarald Vik‐MoDeborah Heart and Lung Center

Discussion

Member takes

Implication

May indicate subclinical diastolic impairment in type 1 diabetes; hypothesis-generating and should not yet change practice.

Key Points

To evaluate left ventricular diastolic function at rest and during exercise in young men with long-term type 1 diabetes lacking overt heart disease.
Assessed 10 young men (under 40 years) with long-term type 1 diabetes (≥12 years) and 10 healthy control subjects.
Recorded digitized M-mode echocardiograms at rest and during semisupine bicycle exercise at 50 W and 100 W workloads.
Diabetic participants had higher heart rates at peak exercise and smaller left ventricular end-diastolic dimensions across all study phases compared to controls.
Covariance analysis adjusting for heart rate showed that diabetic subjects had a significantly lower normalized peak rate of dimension increase both at rest (18% lower) and at peak exercise (20% lower).

Structured PICO

Does long-term type 1 diabetes impair left ventricular diastolic function at rest and during exercise in young men without overt heart disease?

Population

n=20 men, comprising 10 relatively young (<40 years) long-term (≥12 years) type 1 (insulin-dependent) diabetic men without overt heart disease, and 10 controls.

Intervention

Semisupine bicycle exercise (workloads of 50 and 100 W) with digitized M-mode echocardiography

Comparator

Healthy controls undergoing the same exercise protocol

Outcome

Left ventricular diastolic peak rate of dimension increase at rest and during exercisesurrogate

Young men with long-term type 1 diabetes without overt heart disease exhibit subclinical left ventricular diastolic dysfunction both at rest and during exercise.

Cite This Study

Daníelsen et al. (1988) studied this question.

synapsesocial.com/papers/6a71290c2163a0a01bc5544c https://doi.org/10.1093/oxfordjournals.eurheartj.a062516

Topics

Echocardiography

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Left ventricular diastolic function in young long-term type 1 (insulin-dependent) diabetic men during exercise assessed by digitized echocardiography

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Left ventricular diastolic function in young long-term type 1 (insulin-dependent) diabetic men during exercise assessed by digitized echocardiography

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider