What question did this study set out to answer?

To evaluate left ventricular diastolic function and relaxation dynamics in diabetic patients across varying degrees of microvascular complications.

May 1, 1982HeartOpen Access

Echocardiographic features of impaired ventricular function in diabetes mellitus.

Q: What does this research mean for the field?

Diabetes mellitus with microvascular complications is associated with impaired left ventricular diastolic function, specifically characterized by a prolonged duration and reduced rate of posterior wall thinning that is distinct from abnormalities caused by coronary artery disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Why the study?

Does diabetes mellitus affect left ventricular diastolic function compared to normal subjects and patients with coronary artery disease?

Population

142 diabetics (free from heart disease), 20 normal subjects, and 16 patients with coronary artery disease

Design

Cross-sectional

Authors

LSLeonard M. ShapiroStructural Heart Disease

Discussion

Member takes

Implication

Diabetic microangiopathy may impair LV diastolic function independent of CAD; leaves open prognostic impact and screening implications.

Key Points

To evaluate left ventricular diastolic function and relaxation dynamics in diabetic patients across varying degrees of microvascular complications.
Recorded simultaneous echocardiograms and phonocardiograms in 142 diabetic patients without overt heart disease, 20 healthy controls, and 16 patients with coronary artery disease.
Digitized traces to measure left ventricular relaxation variables, rate and duration of cavity dimension increase, and posterior wall thinning.
Mitral valve opening was significantly delayed relative to minimum cavity dimension and aortic valve closure in all diabetic subgroups except 12 young uncomplicated patients.
Forty-four diabetics with severe microvascular complications showed significantly reduced peak rate and prolonged duration of wall thinning and dimension increase, a pattern distinct from coronary artery disease.
Severity of microvascular complications and diabetes duration (in 42 juvenile-onset patients) correlated significantly with diastolic function abnormalities, including incoordinate isovolumic relaxation in 31 patients.

Structured PICO

Does diabetes mellitus affect left ventricular diastolic function compared to normal subjects and patients with coronary artery disease?

Population

142 diabetics (free from heart disease), 20 normal subjects, and 16 patients with coronary artery disease

Comparator

Normal subjects and patients with coronary artery disease

Outcome

Left ventricular diastolic function (left ventricular relaxation, rate and duration of cavity dimension increase and wall thinning)surrogate

Diabetic microangiopathy is associated with impaired left ventricular diastolic function, characterized by prolonged duration and reduced rate of posterior wall thinning, independent of coronary artery disease.

Cite This Study

Leonard M. Shapiro (1982) studied this question.

synapsesocial.com/papers/6a158cac79ff98d0de4ecc40 https://doi.org/10.1136/hrt.47.5.439

Topics

Echocardiography

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Echocardiographic features of impaired ventricular function in diabetes mellitus.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Echocardiographic features of impaired ventricular function in diabetes mellitus.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Topics

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