Stopping randomized trials earlier than planned due to apparent large beneficial treatment effects at interim analyses can have far-reaching and harmful consequences.
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When interim analyses of randomised trials suggest large beneficial treatment effects, investigators sometimes terminate trials earlier than planned. Gordon H Guyatt and colleagues show how this practice can have far reaching and harmful consequences
Guyatt et al. (Fri,) reported a other. Stopping randomized trials earlier than planned due to apparent large beneficial treatment effects at interim analyses can have far-reaching and harmful consequences.