Key result
Stopping randomized trials earlier than planned due to apparent large beneficial treatment effects at interim analyses can have far-reaching and harmful consequences.
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Design
Editorial
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Highlights the methodological dangers and potential harms of terminating randomized trials early based on interim analyses showing large beneficial effects.
Guyatt et al. (2012) studied this question. Stopping randomized trials earlier than planned due to apparent large beneficial treatment effects at interim analyses can have far-reaching and harmful consequences.
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