June 7, 2005Open Access
Long-Term Response to Calcium Channel Blockers in Idiopathic Pulmonary Arterial Hypertension
Structured PICO
What are the hemodynamic characteristics of long-term calcium channel blocker responders in patients with idiopathic pulmonary arterial hypertension?
P
Population
Idiopathic Pulmonary Arterial Hypertension (IPAH) patients evaluated in a pulmonary vascular referral center
I
Intervention
Calcium channel blockers (CCB)
O
Outcome
Mean pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) during acute vasodilator testingsurrogate
Long-term responders to calcium channel blockers in IPAH are rare (<10%) but exhibit near-normal hemodynamics during acute vasodilator testing.
Abstract
Long-term CCB responders represent <10% of IPAH patients evaluated in a pulmonary vascular referral center. During acute vasodilator testing, these patients showed significantly lower levels of both mean PAP and PVR, which reached near-normal values.
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Authors
Olivier Sitbon
Vascular Medicine
Marc Humbert
Vascular Medicine
X
Xavier Jaïs
Vascular Medicine
Journals
Circulation
Actions
Institutions
Assistance Publique – Hôpitaux de Paris
Hôpital Antoine-Béclère
References and Citations
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