Serum markers of collagen degradation, including free MMP-1, were significantly elevated in patients with dilated cardiomyopathy compared to controls (5.29 vs. 2.22 ng/ml; P=0.01).
Case-Control (n=90)
Are serum markers of collagen degradation elevated in patients with mild to moderate dilated cardiomyopathy compared to healthy controls?
Serum markers of collagen degradation, such as MMP-1 and ICTP, are elevated in patients with mild to moderate dilated cardiomyopathy and correlate with left ventricular dilation and cardiac index.
Absolute Event Rate: 5.29% vs 2.22%
p-value: p=0.01
BACKGROUND AND AIMS: Left ventricular (LV) dilation and myocardial remodelling are hallmarks of heart failure in idiopathic dilated cardiomyopathy (DCM). Interstitial collagen is essential for LV integrity and function while degradation of collagen by collagenases, especially matrix-metalloproteinases (MMPs), are suggested to contribute to ventricular dilation. In the present study, serological markers of collagen metabolism were investigated. METHODS AND RESULTS: Serum levels of MMP-1 and its inhibitor (TIMP-1), the markers for collagen degradation type I (collagen carboxyterminal telopeptide (ICTP)) and synthesis (carboxyterminal propeptide of type I procollagen (PICP)) were quantified by ELISA and RIA of 43 patients with DCM and 47 age-matched control subjects. Free MMP-1 serum concentration was significantly increased in the DCM group (5.29+/-0.83 vs. 2.22+/-0.29 ng/ml; P=0.01) as well as the free TIMP-1 concentration (206.54+/-12.65 vs. 181.44+/-8.55 ng/ml; P=0.05). The free MMP-1/TIMP-1-ratio was higher in DCM than in the control group (0.030+/-0.005 vs. 0.012+/-0.001; P=0.01). ICTP was significantly increased (7.60+/-1.21 vs. 3.44+/-0.19 microg/l; P<0.001). PICP was not significantly increased (125.29+/-8.93 microg/l vs. 113.11+/-5.47 microg/l; P=n.s.). Free MMP-1 and MMP-1/TIMP-1-ratio correlated with LV end diastolic diameter cm/m(2) body surface area (BSA) (r=0.28; P=0.03 and r=0.34; P=0.01, respectively) as well as with cardiac index (CI) (r=-0.32; P=0.04 and r=-0.33; P=0.04, respectively) in patients with DCM. CONCLUSION: Serum markers of collagen degradation are elevated and might be valuable markers for progression of LV dilation in patients with DCM.
Schwartzkopff et al. (Thu,) conducted a case-control in Dilated Cardiomyopathy (n=90). Serum markers of collagen metabolism vs. Age-matched control subjects was evaluated on Free MMP-1 serum concentration (ng/ml) (p=0.01). Serum markers of collagen degradation, including free MMP-1, were significantly elevated in patients with dilated cardiomyopathy compared to controls (5.29 vs. 2.22 ng/ml; P=0.01).
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