Key result
Serum markers of collagen degradation, including free MMP-1, were significantly elevated in patients with dilated cardiomyopathy compared to controls (5.29 vs. 2.22 ng/ml; P=0.01).
Why the study?
Are serum markers of collagen degradation elevated in patients with mild to moderate dilated cardiomyopathy compared to healthy controls?
Population
90 subjects, comprising 43 patients with mild to moderate idiopathic dilated cardiomyopathy and 47…
Design
Case-control
Authors
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May reflect matrix remodeling in mild-moderate DCM; hypothesis-generating and requires prospective validation before clinical use.
Case-Control (n=90)
Are serum markers of collagen degradation elevated in patients with mild to moderate dilated cardiomyopathy compared to healthy controls?
Absolute Event Rate: 5.29% vs 2.22%
p-value: p=0.01
Serum markers of collagen degradation, such as MMP-1 and ICTP, are elevated in patients with mild to moderate dilated cardiomyopathy and correlate with left ventricular dilation and cardiac index.
Schwartzkopff et al. (2002) conducted a case-control in Dilated Cardiomyopathy (n=90). Serum markers of collagen metabolism vs. Age-matched control subjects was evaluated on Free MMP-1 serum concentration (ng/ml) (p=0.01). Serum markers of collagen degradation, including free MMP-1, were significantly elevated in patients with dilated cardiomyopathy compared to controls (5.29 vs. 2.22 ng/ml; P=0.01).
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