A CD4 count less than 200/mm3 was significantly associated with an increased risk of acute myocardial infarction in patients with HIV (OR 1.74; 95% CI 1.07-2.81; P=0.02).
Cohort (n=6,517)
Effect estimate: OR 1.74 (95% CI 1.07 to 2.81)
p-value: p=0.02
BACKGROUND: The effects of immunologic and virologic factors on acute myocardial infarction (AMI) rates in patients with HIV are unclear. METHODS: HIV-infected patients in a US healthcare system were assessed for AMI. RESULTS: Of 6517 patients with HIV, 273 (4.2%) had an AMI. In a model adjusting for cardiovascular risk factors, antiretroviral medications, and HIV parameters, CD4 count less than 200/mm (odds ratio, 1.74; 95% confidence interval, 1.07 to 2.81; P = 0.02) predicted AMI. Increased HIV viral load was associated with AMI accounting for cardiovascular disease risk factors and antiretroviral medications but was not significant when CD4 count was considered. CONCLUSIONS: Immunologic control appears to be the most important HIV-related factor associated with AMI.
Triant et al. (Wed,) conducted a cohort in HIV (n=6,517). CD4 count <200/mm3 was evaluated on Acute myocardial infarction (OR 1.74, 95% CI 1.07 to 2.81, p=0.02). A CD4 count less than 200/mm3 was significantly associated with an increased risk of acute myocardial infarction in patients with HIV (OR 1.74; 95% CI 1.07-2.81; P=0.02).