Key result
A CD4 count less than 200/mm3 was associated with an increased risk of acute myocardial infarction in patients with HIV.
Why the study?
Are immunologic and virologic factors associated with acute myocardial infarction rates in HIV-infected patients?
Cohort (n=6,517)
Are immunologic and virologic factors associated with acute myocardial infarction rates in HIV-infected patients?
Poor immunologic control (CD4 count < 200/mm³) is a significant independent predictor of acute myocardial infarction in patients with HIV.
Answers are grounded in this paper and cite their sources.
May inform AMI risk stratification by CD4 in HIV; leaves open whether immunologic recovery modifies events.
BACKGROUND: The effects of immunologic and virologic factors on acute myocardial infarction (AMI) rates in patients with HIV are unclear. METHODS: HIV-infected patients in a US healthcare system were assessed for AMI. RESULTS: Of 6517 patients with HIV, 273 (4.2%) had an AMI. In a model adjusting for cardiovascular risk factors, antiretroviral medications, and HIV parameters, CD4 count less than 200/mm (odds ratio, 1.74; 95% confidence interval, 1.07 to 2.81; P = 0.02) predicted AMI. Increased HIV viral load was associated with AMI accounting for cardiovascular disease risk factors and antiretroviral medications but was not significant when CD4 count was considered. CONCLUSIONS: Immunologic control appears to be the most important HIV-related factor associated with AMI.
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Triant et al. (2010) conducted a cohort in HIV (n=6,517). CD4 count <200/mm3 was evaluated on Acute myocardial infarction (OR 1.74, 95% CI 1.07 to 2.81, p=0.02). A CD4 count less than 200/mm3 was associated with an increased risk of acute myocardial infarction in patients with HIV.
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