Overnight and morning urine collections predicted 24-hour microalbuminuria with 90% sensitivity and 88% specificity, demonstrating they are reliable alternatives for diagnosis.
Cross-Sectional (n=54)
With the aim of comparing different urine collection periods in the assessment of micro-albuminuria, urinary albumin excretion rates (AERs) were measured in samples from 24 h, overnight, and morning urine collections in 54 patients aged 17 to 62 years with insulin-dependent diabetes mellitus with a mean duration of 15 years. The AER in overnight urine was found to be reduced by 25% compared to the rate in 24 h and morning urine. Assessing the ability to predict a 24 h AER within the microalbuminuric range (20-200 micrograms/min) we found a sensitivity of 90% and a specificity of 88% for both overnight and morning urine samples. These values were slightly improved by relating AER to the excretion of creatinine and it is concluded that overnight as well as morning urine collections can be used when diagnosing microalbuminuria in insulin-dependent diabetics. Furthermore the results show that the albumin to creatinine ratio in morning urine is a reliable estimate of 24 h AER and better than measurement of the albumin concentration alone.
Eshøj et al. (Thu,) conducted a cross-sectional in Insulin-dependent diabetes mellitus (n=54). Overnight and morning urine collections vs. 24-hour urine collection was evaluated on Ability to predict a 24-hour albumin excretion rate within the microalbuminuric range (20-200 micrograms/min). Overnight and morning urine collections predicted 24-hour microalbuminuria with 90% sensitivity and 88% specificity, demonstrating they are reliable alternatives for diagnosis.