Intravenous administration of angiotensin fragments Val-Tyr and ANG III significantly reduced diastolic blood pressure in spontaneously hypertensive rats.
Absolute Event Rate: 1.75% vs 3.07%
When angiotensin fragments, Val-Tyr and Angiotensin III (ANG III), with potent ACE inhibitory activity were intravenously administered to spontaneously hypertensive rat (SHR), a significant reduction of diastolic blood pressure was observed. After incubation of ANG III with SHR plasma, four fragments with ACE inhibitory activity, Val-Tyr (ANG (3-4)) (IC50 = 26.0 microM), Ile-His-Pro-Phe (ANG (5-8)) (11.6 microM), Tyr-Ile-His-Pro-Phe (ANG (4-8)) (457.5 microM), and Val-Tyr-Ile-His-Pro-Phe (ANG (3-8)) (6.55 microM), were confirmed to generate in SHR plasma. Compared the metabolic behavior of ANG II in SHR plasma with that in normotensive Wistar plasma, the initial degradation rate (3.07 nmol/ml/min) in Wistar plasma was about 2-fold higher than that in the SHR one (1.75 nmol/ml/min).
Matsufuji et al. (Sun,) conducted a other in Spontaneously hypertensive rat (SHR). Angiotensin fragments (Val-Tyr and Angiotensin III) vs. Normotensive Wistar rats was evaluated on Diastolic blood pressure reduction and initial degradation rate. Intravenous administration of angiotensin fragments Val-Tyr and ANG III significantly reduced diastolic blood pressure in spontaneously hypertensive rats.