Key result
Intravenous administration of angiotensin fragments Val-Tyr and ANG III significantly reduced diastolic blood pressure in spontaneously hypertensive rats.
Why the study?
Do angiotensin fragments (Val-Tyr and Angiotensin III) reduce blood pressure in spontaneously hypertensive rats?
Do angiotensin fragments (Val-Tyr and Angiotensin III) reduce blood pressure in spontaneously hypertensive rats?
Angiotensin fragments Val-Tyr and Angiotensin III exhibit potent ACE inhibitory activity and significantly reduce diastolic blood pressure in spontaneously hypertensive rats.
Answers are grounded in this paper and cite their sources.
Does not support clinical use; leaves open translation of Val-Tyr/ANG III effects to human hypertension.
When angiotensin fragments, Val-Tyr and Angiotensin III (ANG III), with potent ACE inhibitory activity were intravenously administered to spontaneously hypertensive rat (SHR), a significant reduction of diastolic blood pressure was observed. After incubation of ANG III with SHR plasma, four fragments with ACE inhibitory activity, Val-Tyr (ANG (3-4)) (IC50 = 26.0 microM), Ile-His-Pro-Phe (ANG (5-8)) (11.6 microM), Tyr-Ile-His-Pro-Phe (ANG (4-8)) (457.5 microM), and Val-Tyr-Ile-His-Pro-Phe (ANG (3-8)) (6.55 microM), were confirmed to generate in SHR plasma. Compared the metabolic behavior of ANG II in SHR plasma with that in normotensive Wistar plasma, the initial degradation rate (3.07 nmol/ml/min) in Wistar plasma was about 2-fold higher than that in the SHR one (1.75 nmol/ml/min).
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Matsufuji et al. (1995) studied Spontaneously hypertensive rat (SHR). Angiotensin fragments (Val-Tyr and Angiotensin III) vs. Normotensive Wistar rats was evaluated on Diastolic blood pressure reduction and initial degradation rate. Intravenous administration of angiotensin fragments Val-Tyr and ANG III significantly reduced diastolic blood pressure in spontaneously hypertensive rats.
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