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Maintaining a constant heart rate during isoproterenol infusion allows for the separation of its peripheral and central hemodynamic effects on circulation in humans. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

March 1, 1965Open Access

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Stroke Volume and Peripheral Resistance during Infusion of Isoproterenol at a Constant Fixed Heart Rate

ABAlberto BenchimolGood Samaritan Hospital ELEvandro LucenaInstituto Nacional do Câncer EDE. Grey DimondAmerican College of Radiology

Structured PICO

What are the hemodynamic consequences of isoproterenol infusion when heart rate is maintained constant in humans?

Population

Humans

Intervention

Infusion of isoproterenol with heart rate maintained constant

Outcome

Hemodynamic consequences (stroke volume and peripheral resistance)surrogate

This study aims to separate the peripheral from the central hemodynamic effects of isoproterenol by maintaining a constant heart rate during infusion.

Abstract

THE hemodynamic effects of isoproterenol have been described in the literature in a variety of clinical1-2 and experimental conditions.13-16 In these reports, the action of this drug on the heart rate and stroke volume has been emphasized. However, no attempt has been made to study its hemodynamic conse- quences in man when the heart rate is maintained constant throughout the experiment. Under this circumstance it is possible to separate the peripheral from the central effects of this drug on the circulation.

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Stroke Volume and Peripheral Resistance during Infusion of Isoproterenol at a Constant Fixed Heart Rate

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Abstract

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