Why the study?
What are the hemodynamic consequences of isoproterenol infusion when heart rate is maintained constant in humans?
What are the hemodynamic consequences of isoproterenol infusion when heart rate is maintained constant in humans?
This study aims to separate the peripheral from the central hemodynamic effects of isoproterenol by maintaining a constant heart rate during infusion.
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Constant heart rate during isoproterenol infusion may isolate peripheral effects; leaves open clinical translation pending higher-level evidence.
THE hemodynamic effects of isoproterenol have been described in the literature in a variety of clinical1-2 and experimental conditions.13-16 In these reports, the action of this drug on the heart rate and stroke volume has been emphasized. However, no attempt has been made to study its hemodynamic conse- quences in man when the heart rate is maintained constant throughout the experiment. Under this circumstance it is possible to separate the peripheral from the central effects of this drug on the circulation.
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Benchimol et al. (1965) studied this question.
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