Why the study?
What is the effect of heart rate and intracoronary isoproterenol, levarterenol, and epinephrine on coronary flow and resistance?
Population
Perfused hearts (stopped and beating)
Design
Preclinical
Authors
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Animal data suggest intravascular dominance in coronary resistance reduction; hypothesis-generating for human coronary flow studies.
What is the effect of heart rate and intracoronary isoproterenol, levarterenol, and epinephrine on coronary flow and resistance?
Intracoronary isoproterenol, levarterenol, and epinephrine decrease total coronary resistance primarily through intravascular effects, with negligible impact on extravascular resistance.
Lewis et al. (1961) studied this question.
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