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April 1, 1963CirculationOpen Access

Hemodynamic Effects of Isoproterenol Infusion in Patients with Normal and Diseased Mitral Valves

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Why the study?

Does isoproterenol infusion alter hemodynamic parameters in patients with normal and diseased mitral valves?

Population

26 patients with and without mitral valve disease undergoing combined right and left heart catheterization

Design

Other

Authors

RWRobert E. WhalenUnited States Department of Veterans AffairsACAllan I. CohenSt. Joseph's HospitalRSRobert G. SumnerSarcoma Oncology Center

Discussion

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Implication

May raise left atrial pressures in mitral stenosis; hypothesis-generating and should not change practice.

Key Points

  • To assess the hemodynamic effects of isoproterenol infusion in individuals with normal versus diseased mitral valves.
  • Evaluated 26 individuals with and without mitral valve disease during combined right and left heart catheterization.
  • Measured systemic and intracardiac pressures, vascular resistance, heart rate, and cardiac output during isoproterenol infusion.
  • Across all valve conditions, isoproterenol increased heart rate and cardiac output while decreasing left ventricular end-diastolic pressure, pulmonary vascular resistance, and total peripheral resistance.
  • Mean left atrial and pulmonary artery pressures decreased in individuals with normal valves or mitral insufficiency, but increased in those with mitral stenosis.
  • Stroke volume tended to increase in all participants except those with mitral stenosis, where concomitant insufficiency attenuated this abnormal response.

Structured PICO

Does isoproterenol infusion alter hemodynamic parameters in patients with normal and diseased mitral valves?

P
Population
26 patients with and without mitral valve disease undergoing combined right and left heart catheterization
I
Intervention
Isoproterenol infusion
O
Outcome
Hemodynamic effects (including heart rate, cardiac output, left ventricular end-diastolic pressure, pulmonary vascular resistance, total peripheral resistance, mean arterial blood pressure, diastolic filling period, mean left atrial and pulmonary artery pressures, and stroke volume)surrogate

Isoproterenol infusion produces distinct hemodynamic responses in patients with mitral stenosis compared to those with normal or insufficient mitral valves, notably increasing left atrial and pulmonary artery pressures.

Cite This Study

Whalen et al. (1963) studied this question.

synapsesocial.com/papers/6a7bd8444fcef545fadf8a01https://doi.org/10.1161/01.cir.27.4.512

Topics

Mitral valve intervention
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