Why the study?
Does intravenous isoproterenol alter pulmonary blood volume and distending pressure differently depending on the underlying cardiac pathology?
Population
34 patients with valvular heart disease or primary myocardial disease, and 1 normal subject.
Design
Cohort
Authors
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May guide acute management in select cardiac diseases; hypothesis-generating and leaves open randomized confirmation.
Does intravenous isoproterenol alter pulmonary blood volume and distending pressure differently depending on the underlying cardiac pathology?
Intravenous isoproterenol exerts differential hemodynamic effects on the pulmonary vascular bed depending on the underlying cardiac pathology, involving multiple mechanisms such as active vasodilation and positive inotropy.
Schreiner et al. (1968) studied this question.