Why the study?
Does isoproterenol alter pulmonary blood volume and pulmonary vascular resistance in subjects with rheumatic heart disease?
Population
42 subjects total: 5 hemodynamically normal subjects and 37 patients with heart disease.
Comparison
Isoproterenol 10 to 20 mg administered… vs Hemodynamically normal subjects and…
Design
Cohort
Authors
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Elevated pulmonary blood volume in mitral stenosis was associated with isoproterenol-induced increases; leaves open whether these hemodynamic effects warrant clinical consideration in rheumatic heart disease.
Does isoproterenol alter pulmonary blood volume and pulmonary vascular resistance in subjects with rheumatic heart disease?
Pulmonary blood volume is significantly elevated in patients with moderate to severe mitral stenosis and is further increased acutely by sublingual isoproterenol, indicating increased distensibility of the pulmonary vascular bed.
McGaff et al. (1963) studied this question.
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