Females with depressive symptoms at baseline had a significantly higher risk of developing metabolic syndrome over 7 years (OR 2.5; 95% CI 1.2-5.2), whereas no risk difference was observed in men.
Cohort (n=1,294)
Do depressive symptoms increase the risk of developing metabolic syndrome in a middle-aged population?
Depressive symptoms, particularly melancholic symptoms, significantly increase the long-term risk of developing metabolic syndrome in middle-aged women, highlighting depression as a sex-specific predisposing factor for cardiometabolic risk.
Effect estimate: OR 2.5 (95% CI 1.2-5.2)
OBJECTIVE: To evaluate the risk for developing metabolic syndrome when having depressive symptoms. METHOD: The prevalence of depressive symptoms and metabolic syndrome at baseline, and after a 7-year follow-up as measured with Beck depression inventory (BDI), and using the modified National Cholesterol Education Program--Adult Treatment Panel III criteria for metabolic syndrome (MetS) were studied in a middle-aged population-based sample (n = 1294). RESULTS: The logistic regression analysis showed a 2.5-fold risk (95% CI: 1.2-5.2) for the females with depressive symptoms (BDI >or=10) at baseline to have MetS at the end of the follow-up. The risk was highest in the subgroup with more melancholic symptoms evaluated with a summary score of the melancholic items in BDI (OR 6.81, 95% CI: 2.09-22.20). In men, there was no risk difference. CONCLUSION: The higher risks for MetS in females with depressive symptoms at baseline suggest that depression may be an important predisposing factor for the development of MetS.
Vanhala et al. (Wed,) conducted a cohort in Depressive symptoms and metabolic syndrome (n=1,294). Depressive symptoms vs. No depressive symptoms was evaluated on Development of metabolic syndrome (MetS) (OR 2.5, 95% CI 1.2-5.2). Females with depressive symptoms at baseline had a significantly higher risk of developing metabolic syndrome over 7 years (OR 2.5; 95% CI 1.2-5.2), whereas no risk difference was observed in men.
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