An 8-week exercise training regimen improved insulin-stimulated glucose disposal and increased the vasodilatory response to acetylcholine in overweight and type 2 diabetic subjects (P<0.05).
Observational
Does an 8-week exercise training regimen improve vasodilatory function and insulin sensitivity in overweight, insulin-resistant subjects and type 2 diabetic patients?
An 8-week aerobic exercise training regimen improves both endothelium-dependent vasodilation and insulin sensitivity in overweight and type 2 diabetic patients.
p-value: p=<0.05
OBJECTIVE: The present study was undertaken to determine whether improved vasodilatory function accompanies increased insulin sensitivity in overweight, insulin-resistant subjects (OW) and type 2 diabetic patients (T2DM) who participated in an 8-wk exercise training regimen. DESIGN: Before and after training, subjects had euglycemic clamps to determine insulin sensitivity. Brachial artery catheterization was done on another occasion for measurement of vasodilatory function. A lean, healthy, untrained group was studied as nonexercised controls. RESULTS: Training increased oxygen consumption (VO2) peak OW, 29 +/- 1 to 37 +/- 4 ml/kg fat-free mass (FFM).min; T2DM, 33 +/- 2 to 43 +/- 3 ml/kg FFM.min; P < 0.05 and improved insulin-stimulated glucose disposal (OW, 6.5 +/- 0.5 to 7.2 +/- 0.4 mg/kg FFM.min; T2DM, 3.8 +/- 0.3 to 4.2 +/- 0.3 mg/kg FFM.min; P < 0.05) in insulin resistance. OW and T2DM, before training, had decreased acetylcholine chloride (ACh)- and sodium nitroprusside-mediated vasodilation and decreased reactive hyperemia compared with lean controls. Training increased the vasodilatory response to ACh OW (30 microg ACh/min), 12.2 +/- 3.4 to 19 +/- 4.2 ml/100 g.min; T2DM (30 microg ACh/min), 10.1 +/- 1.5 to 14.2 +/- 2.1 ml/100 g.min; P < 0.05 in both groups without affecting nitroprusside response. CONCLUSION: Because vasodilatory dysfunction has been postulated to contribute to insulin resistance, the exercise-induced improvement in vasodilatory function may signify changes in the endothelium that could contribute to the improvement in insulin sensitivity observed after aerobic exercise training.
Filippis et al. (Wed,) conducted a observational in Overweight, insulin resistance, and type 2 diabetes mellitus. Exercise training regimen vs. Lean, healthy, untrained nonexercised controls was evaluated on Insulin sensitivity and vasodilatory function (p=<0.05). An 8-week exercise training regimen improved insulin-stimulated glucose disposal and increased the vasodilatory response to acetylcholine in overweight and type 2 diabetic subjects (P<0.05).
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