Prolonged systemic inflammation is hypothesized to cause coronary microvascular dysfunction in patients without traditional CAD risk factors.
A reduced CFR in the absence of significant coronary disease is suggestive of CMD. We speculate that this is the consequence of prolonged systemic inflammation, which may precede and contribute to premature coronary artery disease in these patients.
Recio‐Mayoral et al. (Fri,) studied this question.
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