Prolonged systemic inflammation is hypothesized to cause coronary microvascular dysfunction in patients without traditional CAD risk factors.
Hypothesis-generating link between inflammation and reduced CFR without CAD; prospective trials needed before any clinical implications.
A reduced CFR in the absence of significant coronary disease is suggestive of CMD. We speculate that this is the consequence of prolonged systemic inflammation, which may precede and contribute to premature coronary artery disease in these patients.
No takes yet. Share an insight, caveat, or question.
Recio‐Mayoral et al. (2009) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: