Why the study?
Does systemic lupus erythematosus increase the risk of myocardial infarction and angina in women compared to the general population?
Population
498 women with systemic lupus erythematosus seen at the University of Pittsburgh Medical Center from 1980 to…
Comparison
Systemic lupus erythematosus (disease exposure) vs 2,208 women of similar age participating in the…
Design
Cohort
Follow-up
3,522 person-years for SLE cohort, 17,519 person-years for…
Authors
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May warrant closer MI surveillance in young women with SLE; leaves open whether targeted prevention alters outcomes.
Does systemic lupus erythematosus increase the risk of myocardial infarction and angina in women compared to the general population?
Premature cardiovascular disease, specifically myocardial infarction, is markedly more common in young premenopausal women with systemic lupus erythematosus compared to the general population.
Manzi et al. (1997) studied this question.