Dobutamine infusion increased stroke volume from a median of 99 mL to 114 mL (P<0.05) and increased early and atrial peak filling rates as measured by MR flow mapping.
Observational (n=10)
Absolute Event Rate: 114% vs 99%
p-value: p=<0.05
PURPOSE: To evaluate the ability of MR flow mapping to measure changes in left ventricular filling during beta-adrenergic stimulation. MATERIALS AND METHODS: Mitral flow was measured in 10 healthy volunteers using conventional free breathing fast-field echo (FFE) with a spatial resolution of 2.7 x 2.2 mm and a temporal resolution of 22 msec. The sequence was repeated during dobutamine infusion (20 microg/kg/minute). RESULTS: Stroke volume increased from a median of 99 mL (range: 68-142 mL) (Note: values as presented are medians and ranges, throughout) to 114 mL (87-180 mL) (P < 0.05). Both early (E) peak filling rate (554 mL/second 433-497 mL to 651 mL/second 496-1096 mL/second) (P < 0.05) and atrial (A) peak filling rate (238 mL/second 183-352 mL/second to 341 mL/second 230-538 mL/second) (P < 0.05) increased. These changes, together with the increase in E acceleration peak and A deceleration peak, were consistent with facilitated myocardial relaxation. CONCLUSION: Conventional free breathing FFE has the ability to measure the effects of beta-adrenergic stimulation on left ventricular filling.
Paelinck et al. (Wed,) conducted a observational in Healthy volunteers (n=10). Dobutamine infusion vs. Baseline was evaluated on Stroke volume (p=<0.05). Dobutamine infusion increased stroke volume from a median of 99 mL to 114 mL (P<0.05) and increased early and atrial peak filling rates as measured by MR flow mapping.
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