Key result
Dobutamine infusion increased stroke volume from a median of 99 mL to 114 mL and increased early and atrial peak filling rates as measured by MR flow mapping.
Why the study?
Can MR flow mapping measure changes in left ventricular filling during dobutamine-induced beta-adrenergic stimulation in healthy volunteers?
Observational (n=10)
Can MR flow mapping measure changes in left ventricular filling during dobutamine-induced beta-adrenergic stimulation in healthy volunteers?
Conventional free breathing FFE MR flow mapping can effectively measure dobutamine-induced changes in left ventricular diastolic filling.
Answers are grounded in this paper and cite their sources.
Supports MR flow mapping feasibility under stress in volunteers; leaves open validation and utility in patients with diastolic dysfunction.
PURPOSE: To evaluate the ability of MR flow mapping to measure changes in left ventricular filling during beta-adrenergic stimulation. MATERIALS AND METHODS: Mitral flow was measured in 10 healthy volunteers using conventional free breathing fast-field echo (FFE) with a spatial resolution of 2.7 x 2.2 mm and a temporal resolution of 22 msec. The sequence was repeated during dobutamine infusion (20 microg/kg/minute). RESULTS: Stroke volume increased from a median of 99 mL (range: 68-142 mL) (Note: values as presented are medians and ranges, throughout) to 114 mL (87-180 mL) (P < 0.05). Both early (E) peak filling rate (554 mL/second [433-497 mL] to 651 mL/second [496-1096 mL/second]) (P < 0.05) and atrial (A) peak filling rate (238 mL/second [183-352 mL/second] to 341 mL/second [230-538 mL/second]) (P < 0.05) increased. These changes, together with the increase in E acceleration peak and A deceleration peak, were consistent with facilitated myocardial relaxation. CONCLUSION: Conventional free breathing FFE has the ability to measure the effects of beta-adrenergic stimulation on left ventricular filling.
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Paelinck et al. (2004) conducted an observational in Healthy volunteers (n=10). Dobutamine infusion vs. Baseline was evaluated on Stroke volume (p=<0.05). Dobutamine infusion increased stroke volume from a median of 99 mL to 114 mL and increased early and atrial peak filling rates as measured by MR flow mapping.
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