Does gabapentin reduce the frequency of hot flashes?
Gabapentin may act directly upon temperature regulatory centers, reducing hot flashes but potentially exacerbating hypothermia in susceptible patients.
The author describes six cases in which gabapentin treatment reduced the frequency of hot flashes. In addition, gabapentin treatment enhanced the frequency of hypothermic episodes in a separate patient with known hypothalamic dysfunction. Gabapentin may act directly upon temperature regulatory centers.
Thomas Guttuso (Tue,) studied this question.