Why the study?
Does gabapentin reduce the frequency of hot flashes?
Does gabapentin reduce the frequency of hot flashes?
Gabapentin may act directly upon temperature regulatory centers, reducing hot flashes but potentially exacerbating hypothermia in susceptible patients.
Gabapentin warrants caution in hypothalamic dysfunction for hypothermia risk; case reports leave open thermoregulatory effects for controlled study.
The author describes six cases in which gabapentin treatment reduced the frequency of hot flashes. In addition, gabapentin treatment enhanced the frequency of hypothermic episodes in a separate patient with known hypothalamic dysfunction. Gabapentin may act directly upon temperature regulatory centers.
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Thomas Guttuso (2000) studied this question.
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