Adenosine deaminase activity measurement in pericardial effusion using a 40 U/L cut-off demonstrated 89% sensitivity and 72% specificity for diagnosing tuberculous pericarditis.
Case-Control (n=48)
Does the measurement of adenosine deaminase (ADA) activity in pericardial effusion accurately diagnose tuberculous pericarditis compared to other causes of pericardial effusion?
Adenosine deaminase (ADA) activity in pericardial effusion is a clinically useful biomarker for diagnosing tuberculous pericarditis, demonstrating 89% sensitivity and 72% specificity at a 40 U/L cut-off.
Effect estimate: Sensitivity 89%, Specificity 72%
The objective of this study was to evaluate the adenosine deaminase (ADA) activity usefulness in the diagnosis of tuberculous pericarditis (TP), comparing its value with pericardial effusions (PE) caused by other pericardial diseases. A retrospective case-control study was conducted with nine cases of TP and 39 other than TP diseases (12 neoplastic, 11 septic and 16 unknown origin). Every patient included in this study had PE samples submitted to ADA activity measures and microbiological analysis, and then had pericardial tissue samples submitted to microbiological and histopathological examination. Considering the value of 40 U/L as the cut-off for the diagnosis of TP, the specificity and sensitivity were respectively of 72% and 89%. The specificity of ADA activity for the TP was best applied in the differential diagnosis from PE of unknown origin. The present study demonstrates the clinical value of the measurement of ADA activity in PE in the diagnosis of TP.
Tuon et al. (Fri,) conducted a case-control in Tuberculous pericarditis (n=48). Adenosine deaminase (ADA) activity measurement vs. Pericardial effusions caused by other pericardial diseases was evaluated on Diagnostic sensitivity and specificity for tuberculous pericarditis (Sensitivity 89%, Specificity 72%). Adenosine deaminase activity measurement in pericardial effusion using a 40 U/L cut-off demonstrated 89% sensitivity and 72% specificity for diagnosing tuberculous pericarditis.