The role of the RhoA/Rho-kinase signaling pathway in renal vascular reactivity in endothelial nitric oxide synthase null mice

These results show that the ROCK signaling pathway is amplified in the eNOS KO mouse kidney and that the enhanced renal vascular tone and selective increase in reactivity to GPCR agonists supports a role for ROCK in the hypertension and vascular dysfunction in the eNOS KO mice.