Does 4'-chlorodiazepam protect against post-ischaemic cardiac dysfunction in a rabbit heart model of ischaemia-reperfusion injury?
rabbit heart model of ischaemia-reperfusion injury
4'-chlorodiazepam (4-ClDzp) administered upon reperfusion
post-ischaemic cardiac dysfunction and cellular excitation-contraction couplingsurrogate
4'-chlorodiazepam offers protection against ischemia-reperfusion injury in rabbit hearts even when administered at the time of reperfusion.
The findings indicate that the effects of 4-ClDzp on both mitochondrial and sarcolemmal ion channels contribute to protection against post-ischaemic cardiac dysfunction. Of clinical relevance, the compound is effective when given upon reperfusion, unlike other pre-conditioning agents.
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David A. Brown
Miguel A. Aon
Fadi G. Akar
Cardiovascular Research
Johns Hopkins University
Johns Hopkins Medicine
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Brown et al. (Thu,) studied this question.
synapsesocial.com/papers/69d56e1675589c71d767d390 — DOI: https://doi.org/10.1093/cvr/cvn053