Why the study?
Does 4'-chlorodiazepam protect against post-ischaemic cardiac dysfunction in a rabbit heart model of ischaemia-reperfusion injury?
Does 4'-chlorodiazepam protect against post-ischaemic cardiac dysfunction in a rabbit heart model of ischaemia-reperfusion injury?
4'-chlorodiazepam offers protection against ischemia-reperfusion injury in rabbit hearts even when administered at the time of reperfusion.
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Should not yet alter clinical reperfusion strategies; leaves open translation of mitochondrial ion channel effects to human cardioprotection.
The findings indicate that the effects of 4-ClDzp on both mitochondrial and sarcolemmal ion channels contribute to protection against post-ischaemic cardiac dysfunction. Of clinical relevance, the compound is effective when given upon reperfusion, unlike other pre-conditioning agents.
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Brown et al. (2008) studied this question.
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