Does 4'-chlorodiazepam protect against post-ischaemic cardiac dysfunction in a rabbit heart model of ischaemia-reperfusion injury?
4'-chlorodiazepam offers protection against ischemia-reperfusion injury in rabbit hearts even when administered at the time of reperfusion.
The findings indicate that the effects of 4-ClDzp on both mitochondrial and sarcolemmal ion channels contribute to protection against post-ischaemic cardiac dysfunction. Of clinical relevance, the compound is effective when given upon reperfusion, unlike other pre-conditioning agents.
Brown et al. (Thu,) studied this question.