Why the study?
Does diltiazem prevent reperfusion-induced ventricular fibrillation in isolated rat hearts?
Population
Isolated retrogressively perfused rat heart preparation with transient coronary artery occlusion
Comparison
Pre-ischemic administration of d-diltiazem at… vs Control group (no diltiazem)
Design
Preclinical
Authors
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Diltiazem attenuates reperfusion VF in rat hearts; leaves open translation to human reperfusion injury and clinical trials.
Does diltiazem prevent reperfusion-induced ventricular fibrillation in isolated rat hearts?
Diltiazem protects against reperfusion-induced arrhythmias in isolated rat hearts, likely mediated by its specific effect on the slow calcium channel.
Mitani et al. (1990) studied this question.
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