Key result
Intravenous diltiazem significantly reduced the infarcted area as a percentage of the risk area compared to saline in dogs with ischemia-reperfusion injury (27.5% vs 47.0%, p<0.05).
Why the study?
Does diltiazem reduce infarct size in a dog model of ischemia-reperfusion injury?
Population
16 dogs subjected to ischemia-reperfusion injury (LAD occlusion for 40 min, reperfusion for 120 min)
Comparison
Diltiazem intravenously infused at 3 mcg/kg/min… vs Saline intravenously infused
Design
Preclinical, randomly assigned
Follow-up
120 min of reperfusion
Authors
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Hypothesis-generating in canine ischemia-reperfusion; leaves open translation to human myocardial infarction.
RCT (n=16)
Randomized
Does diltiazem reduce infarct size in a dog model of ischemia-reperfusion injury?
Absolute Event Rate: 27.5% vs 47%
p-value: p=<0.05
Diltiazem reduces infarct size and tissue calcium elevation in a canine model of ischemia-reperfusion injury.
Kinoshita et al. (1985) conducted an RCT in Ischemia-reperfusion injury (n=16). Diltiazem hydrochloride vs. Saline was evaluated on Infarcted area as a percentage of the risk area (p=<0.05). Intravenous diltiazem significantly reduced the infarcted area as a percentage of the risk area compared to saline in dogs with ischemia-reperfusion injury (27.5% vs 47.0%, p<0.05).
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