Key result
Diltiazem given during reperfusion significantly reduced infarct size compared to control (20.5% vs 39.8% of area at risk; p<0.05) in dogs with ischaemic myocardium.
Why the study?
Does diltiazem reduce infarct size in a canine model of myocardial ischaemia and reperfusion?
RCT (n=60)
random
Does diltiazem reduce infarct size in a canine model of myocardial ischaemia and reperfusion?
Diltiazem administered during reperfusion significantly reduces infarct size and myocardial neutrophil accumulation in a canine model of ischaemia.
Should not change clinical reperfusion practice; leaves open translation of infarct size reduction to human trials.
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Rousseau et al. (1991) conducted an RCT in Ischaemic myocardium (n=60). Diltiazem vs. Saline perfusion was evaluated on Infarct size as a percentage of area at risk (p=<0.05). Diltiazem given during reperfusion significantly reduced infarct size compared to control (20.5% vs 39.8% of area at risk; p<0.05) in dogs with ischaemic myocardium.
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