Why the study?
Does diltiazem reduce infarct size in a porcine model of ischemia and reperfusion?
Does diltiazem reduce infarct size in a porcine model of ischemia and reperfusion?
Diltiazem pretreatment before ischemia, but not before reperfusion, significantly reduces infarct size in a porcine model, suggesting its protective effect occurs primarily during ischemia.
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Diltiazem pretreatment may merit human trials in ischemia-reperfusion; should not yet change clinical practice.
Klein et al. (1984) studied this question.
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