What is the clinical evidence from this study?

Population: Myocardial ischemia (n=24). Intervention: Diltiazem vs. Non-treated control. Primary outcome: Myocardial tissue levels of creatine phosphate (CP) and pH during ischemia (p=<0.05).

What does this research mean for the field?

Diltiazem at doses of 10^-6 M or higher delays ischemia-induced myocardial creatine phosphate depletion and acidosis primarily through its cardiodepressant effects. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1985The Japanese Journal of PharmacologyOpen Access

Beneficial Effects of Diltiazem on the Ischemic Derangements of the Myocardial Metabolism Assessed by 31P-NMR in the Isolated Perfused Rat Heart

Q: What are the key findings of this study?

Diltiazem at doses of 10^-6 M or higher significantly delayed the onset of ischemia-induced falls in myocardial creatine phosphate and pH, correlating with its cardiodepressant effects.

Q: What does this research mean for the field?

Diltiazem at doses of 10^-6 M or higher delays ischemia-induced myocardial creatine phosphate depletion and acidosis primarily through its cardiodepressant effects. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Diltiazem delays ischemia-induced falls in myocardial creatine phosphate and pH, correlating with cardiodepressant effects.

P<0.05
n=24

Why the study?

The effects of diltiazem on ischemic derangements of myocardial mechanical function and energy metabolism were studied using isolated rat hearts.

Does diltiazem improve myocardial energy metabolism during global ischemia in isolated perfused rat hearts?

Structured PICO

Does diltiazem improve myocardial energy metabolism during global ischemia in isolated perfused rat hearts?

Population

24 isolated perfused hearts from male Wistar rats subjected to 15 minutes of global ischemia to evaluate the metabolic effects of diltiazem.

Intervention

Diltiazem-containing solution (10(-7), 10(-6) and 10(-5) M) perfused for 12 min prior to the induction of global ischemia

Comparator

Control hearts not receiving diltiazem (implied)

Outcome

Myocardial tissue levels of creatine phosphate (CP), ATP, inorganic phosphate (Pi) and pH determined with 31P-NMR, and myocardial mechanical functionsurrogate

Main Result

p-value: p=<0.05

Diltiazem improves myocardial energy metabolism during ischemia in rat hearts, likely due to its cardiodepressant effects reducing energy demand.

Limitations

Isolated animal heart model may not fully replicate in vivo human myocardial ischemia
Global ischemia model excludes the assessment of collateral blood flow effects

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Hypothesis-generating for diltiazem in myocardial ischemia; clinical relevance remains undetermined from this in vitro evidence.

Cite This Study

Nakazawa et al. (1985) studied Myocardial ischemia (n=24). Diltiazem vs. Non-treated control was evaluated on Myocardial tissue levels of creatine phosphate (CP) and pH during ischemia (p=<0.05). Diltiazem at doses of 10^-6 M or higher significantly delayed the onset of ischemia-induced falls in myocardial creatine phosphate and pH, correlating with its cardiodepressant effects.

synapsesocial.com/papers/6ab09b26863a646951ebf5b0 https://doi.org/10.1254/jjp.39.51

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Beneficial Effects of Diltiazem on the Ischemic Derangements of the Myocardial Metabolism Assessed by 31P-NMR in the Isolated Perfused Rat Heart

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Beneficial Effects of Diltiazem on the Ischemic Derangements of the Myocardial Metabolism Assessed by 31P-NMR in the Isolated Perfused Rat Heart

Structured PICO

Main Result

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider