Stealth nanotubes: strategies of shielding carbon nanotubes to evade opsonization and improve biodistribution

Key Points

• The aim is to explore methods of shielding carbon nanotubes to prevent opsonization and improve their distribution in the body.
• Evaluated strategies for shielding carbon nanotubes against opsonization
• Assessed in vivo biocompatibility and biodistribution
• Utilized near-infrared contrast nanoagents for monitoring
• Shielded carbon nanotubes exhibited enhanced biodistribution compared to non-shielded controls
• Significant reduction in macrophage uptake observed in shielded groups
• Improved in vivo biocompatibility demonstrated through various metrics