November 13, 2012Open Access

Inhibition of Cyclooxygenase-2 Reduces Hypothalamic Excitation in Rats with Adriamycin-Induced Heart Failure

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Abstract

These results suggest that PVN COX-2 may be an intermediary step for PVN neuronal activation and excitatory neurotransmitter release, which further contributes to sympathoexcitation and RAS activation in adriamycin-induced heart failure. Treatment with COX-2 inhibitor attenuates sympathoexcitation and RAS activation in adriamycin-induced heart failure.

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Authors

Min Zheng

Centre National de la Recherche Scientifique

Yu‐Ming Kang

Wei Liu

Journals

PLoS ONE

SHILAP Revista de lepidopterología

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Institutions

Xi'an Jiaotong University

Shantou University

Shantou University Medical College

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Inhibition of Cyclooxygenase-2 Reduces Hypothalamic Excitation in Rats with Adriamycin-Induced Heart Failure

Key Points

Abstract

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Discussion

Authors

Journals

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References and Citations

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