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LeFree MT, Simon SB, Mancini GBJ, Bates ER, Vogel RA. A comparison of 35 mm cine film and digital radiographic image recording: implications for quantitative coronary arteriography: film vs. digital coronary quantification. Invest Radiol 1988;23: 176–183. To assess potential differences in the intrinsic properties of image recording media and their impact on quantitative coronary arteriography, we used an automatic quantitative arteriography computer program to analyze cine film and digital radiographc images of a radiographic arterial phantom. The phantom consisted of a lucite plate with precision-drilled lumena ranging from 0.5 to 5.0 mm in diameter. Film images were digitized at 2048 X 2048 pixel resolution, and digital radiographic images were acquired at 512 X 512 and 1024 X 1024 resolution. Arterial geometric diameter, percent diameter stenosis, densitometric relative cross-sectional area, and densitometric percent area stenosis were measured. All three techniques were equivalent in measuring diameters with a high degree of overall accuracy (R > .992). All methods overestimated diameters below 1.0 mm. Both 512 X 512 and 1024 X 1024 digital images were superior to film for densitometric measurement of relative area (R = .995 vs. R = .940, P = .0032). We conclude that automated analysis of digital radiographic images yields results that are similar in geometric precision but greater in densitometric precision than film analysis.
LeFree et al. (Tue,) studied this question.