Invasionsfaktoren uPA/PAI-1 und HER2-Status liefern unabhängig und komplementär Informationen über den Behandlungserfolg bei lyphknoten-negativem Brustkrebs

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Abstract

Nach einer Langzeitbeobachtung deuten die uPA/PAI-1-Spiegel im primären Tumorgewebe zuverlässig und stark auf einen aggressiven Krankheitsverlauf bei lymphknoten-negativem Brustkrebs unabhängig vom HER2-Status hin. Der besondere prognostische Effekt des HER2-Status auf das Gesamtüberleben könnte seine Fähigkeit widerspiegeln, die Resistenz gegen systemische Therapie vorherzusagen.

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Authors

Iris Zemzoum

Klinikum rechts der Isar

Ronald Kates

Stevens Institute of Technology

Jeffrey S. Ross

Rutgers, The State University of New Jersey

Journals

Journal of Clinical Oncology

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Institutions

Albany Medical Center Hospital

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Zemzoum et al. (Do,) haben diese Frage untersucht.

synapsesocial.com/papers/69d845e6d56ca42147d17ffd — DOI: https://doi.org/10.1200/jco.2003.04.170

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Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

The urokinase-type plasminogen activator system in cancer metastasis: A review· 1997 · 1,555 citations
Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2· 2001 · 11,496 citations
Prognostic and Predictive Factors· 2004 · 117 citations
Tumor Marker Utility Grading System: a Framework to Evaluate Clinical Utility of Tumor Markers· 1996 · 752 citations
Do we need prognostic factors in nodal-negative breast cancer?· 2000 · 39 citations

Invasionsfaktoren uPA/PAI-1 und HER2-Status liefern unabhängig und komplementär Informationen über den Behandlungserfolg bei lyphknoten-negativem Brustkrebs

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Abstract

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

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