Is ADP-induced platelet aggregation associated with P2Y12 gene sequence variations in healthy subjects?
The H2 haplotype of the P2Y12 receptor gene is associated with altered ADP-induced platelet aggregation, suggesting a potential genetic basis for variability in atherothrombosis risk and response to antiplatelet drugs.
In healthy subjects, ADP-induced platelet aggregation is associated with a haplotype of the P2Y12 receptor gene. Given the crucial role of the P2Y12 receptor in platelet functions, carriers of the H2 haplotype may have an increased risk of atherothrombosis and/or a lesser clinical response to drugs inhibiting platelet function.
Fontana et al. (Tue,) studied this question.