Is ADP-induced platelet aggregation associated with P2Y12 gene sequence variations in healthy subjects?
Healthy subjects
P2Y12 receptor gene sequence variations (H2 haplotype)
ADP-induced platelet aggregationsurrogate
The H2 haplotype of the P2Y12 receptor gene is associated with altered ADP-induced platelet aggregation, suggesting a potential genetic basis for variability in atherothrombosis risk and response to antiplatelet drugs.
In healthy subjects, ADP-induced platelet aggregation is associated with a haplotype of the P2Y12 receptor gene. Given the crucial role of the P2Y12 receptor in platelet functions, carriers of the H2 haplotype may have an increased risk of atherothrombosis and/or a lesser clinical response to drugs inhibiting platelet function.
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Pierre Fontana
Annabelle Dupont
Sophie Gandrille
Circulation
Inserm
Université Paris Cité
Hôpital Européen Georges-Pompidou
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Fontana et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69da216d0d540cafc58386c5 — DOI: https://doi.org/10.1161/01.cir.0000085073.69189.88
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