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Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia | Synapse

January 7, 2009Open Access

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Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia

Charles G. MullighanSouth Australia Pathology XSXiaoping SuOntario Institute for Cancer Research JZJinghui ZhangRutgers, The State University of New Jersey

Key Points

This research aims to explore the impact of IKZF1 deletion on prognosis in acute lymphoblastic leukemia (ALL).
Analyzed genetic alterations in patients with B-cell-progenitor ALL.
Evaluated prognosis associated with IKZF1 deletion.
IKZF1 deletion is linked to significantly poorer outcomes in B-cell-progenitor ALL patients.

Abstract

Genetic alteration of IKZF1 is associated with a very poor outcome in B-cell-progenitor ALL.

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Cite This Study

Mullighan et al. (Wed,) studied this question.

synapsesocial.com/papers/69dbc6fc37b5141e3ba3d3f5 https://doi.org/https://doi.org/10.1056/nejmoa0808253