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January 7, 2009New England Journal of MedicineOpen Access

Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia

Charles G. Mullighan Xiaoping Su Jinghui Zhang Ina Radtke Letha A. Phillips Christopher B. Miller Jing Ma Wei Liu Cheng Cheng Brenda A. Schulman Richard C. Harvey I‐Ming Chen Robert Clifford William L. Carroll Gregory H. Reaman W. Paul Bowman Meenakshi Devidas Daniela S. Gerhard Wenjian Yang Mary V. Relling Sheila Shurtleff Dario Campana Michael J. Borowitz Ching‐Hon Pui Malcolm A. Smith Stephen P. Hunger Cheryl L. Willman James R. Downing

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Key Points

This research aims to explore the impact of IKZF1 deletion on prognosis in acute lymphoblastic leukemia (ALL).
Analyzed genetic alterations in patients with B-cell-progenitor ALL.
Evaluated prognosis associated with IKZF1 deletion.
IKZF1 deletion is linked to significantly poorer outcomes in B-cell-progenitor ALL patients.

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Implication

Genetic alteration of IKZF1 correlates with poor prognosis in patients with B-cell-progenitor ALL, indicating its significance.

Abstract

Genetic alteration of IKZF1 is associated with a very poor outcome in B-cell-progenitor ALL.

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Cite This Study

Mullighan et al. (2009) studied this question.

synapsesocial.com/papers/69dbc6fc37b5141e3ba3d3f5 https://doi.org/10.1056/nejmoa0808253

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1[Clinical Characteristics and Prognosis of B-cell Acute Lymphoblastic Leukemia Patients with 2025
2Prognostic significance and treatment strategies for IKZF1 deletion in pediatric B-cell precursor acute lymphoblastic leukemia2024 · 6 citations
3Refining risk stratification in paediatric <scp>B‐acute</scp> lymphoblastic leukaemia: Combining <scp><i>IKZF1</i><sup>plus</sup></scp> and Day 15 <scp>MRD</scp> positivity2024 · 8 citations
4The prognostic impact of IKAROS family zinc finger 1 genetic variants rs4132601 polymorphism in acute lymphoblastic leukemia patientsOriginal Research · 2026
5Prognostic significance of IKZF1 deletion subtypes in ph-negative BCP-ALL: Biallelic-null deletion predicts the worst survival in TP53-wild type patients2025 · 1 citations

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An integrated classification of tumor suppressor <i>IKZF1</i> inactivation and oncogenic activation in Philadelphia chromosome‐like acute lymphoblastic leukemia2024
Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1–positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP)2009
Prognostic significance and treatment strategies for IKZF1 deletion in pediatric B-cell precursor acute lymphoblastic leukemia2024

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