Antihypertensive therapy prevented an estimated 86,000 premature cardiovascular deaths in 2001 and generated a benefit-to-cost ratio of at least 6:1.
Observational
Using national survey data and risk equations from the Framingham Heart Study, we quantify the impact of antihypertensive therapy changes on blood pressures and the number and cost of heart attacks, strokes, and deaths. Antihypertensive therapy has had a major impact on health. Without it, 1999-2000 average blood pressures (at age 40+) would have been 10-13 percent higher, and 86,000 excess premature deaths from cardiovascular disease would have occurred in 2001. Treatment has generated a benefit-to-cost ratio of at least 6:1, but much more can be achieved. More effective use of antihypertensive medication would have an impact on mortality akin to eliminating all deaths from medical errors or accidents.
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Cutler et al. (Mon,) conducted a observational in Hypertension. Antihypertensive therapy vs. No antihypertensive therapy was evaluated on Impact on blood pressures, cardiovascular events, and deaths. Antihypertensive therapy prevented an estimated 86,000 premature cardiovascular deaths in 2001 and generated a benefit-to-cost ratio of at least 6:1.